Biocatalysis, involving the use of natural catalysts such as enzymes, offers environmentally friendly and cost-effective alternatives to traditional chemical synthesis . Especially when the reactions involve chiral molecules, biocatalysis provides highly stereoselective biotransformations, or efficient resolutions of enantiomers.

WuXi STA’s comprehensive biocatalysis platform offers a one-stop solution for all of your biocatalysis challenges; this includes enzyme screening, enzyme evolution, enzyme fermentation as well as process development and production.

capability and capacity Biocatalysis

Capability and Capacity

Related Resource

20 Common Enzymatic Reactions

biocatalysis casestudy2 Biocatalysis

Case Study:3-fold Yield for a key RSM after Enzyme Evolution

The RSM molecule is a key chiral RSM for a late-stage API. We use our proprietary enzyme to improve the yield to 3 fold.

Original Route5 step reactionsYield=30% (5 steps)PMI > 100
Enzymatic Route2 step reactions with WuXi STA proprietary enzyme*Yield=90% (2 steps)PMI < 20

* About Enzyme Evolution of Transaminase

  • Natural enzyme conversion <2%
  • Evolved enzyme conversion >95% after 2 rounds of evolution
Seamless collaboration with in-parallel activities among 4 workstreams
Swift sample transport and information sharing from upstream to downstream teams
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