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Advancing Targeted Protein Degraders: Leveraging CMC Strategies for Rapid IND Submission and Bioavailability Solutions
From: manufacturing CHEMIST Published on September 16, 2024 Abstract: In the rapidly evolving pharmaceutical landscape, targeted protein degraders (TPDs) represent a significant leap forward. TPDs offer a novel therapeutic modality
Flow-Chemistry Enabled Process Development Employing Organometallics
Flow-Chemistry Enabled Process Development Employing Organometallics View now
Development, Problem-solving and Successful Scale-up of a Sterically Hindered Suzuki Coupling Reaction
Development, Problem-solving and Successful Scale-up of a Sterically Hindered Suzuki Coupling Reaction View now
Overcoming Key Challenges in PROTAC Drug Development
Overview: Pharmaceutical development of PROTAC (Proteolysis Targeting Chimeras) molecules presents significant challenges due to their complex molecular structures, leading to low yields, scalability issues, and poor aqueous solubility. These complications
Efficient and Inexpensive Synthesis of a Functionalized Pyrimidine
Efficient and Inexpensive Synthesis of a Functionalized Pyrimidine View now
